Wen Xie, associate professor of pharmaceutical sciences, received a two-year NIH grant for $416,625 for “The Regulation of Human Hydroxysteroid Sulfotransferase by Nuclear Receptor ROR.”

The goal of this project is to study the regulation of the human hydroxysteroid sulfotransferase (SULT2A1), a Phase II drug-metabolizing enzyme, by the retinoid-related orphan receptors (RORs). RORs are previously known for their roles in tissue development and circadian rhythm. SULT2A1 is important for the metabolism of bile acids and relief of cholestasis. Results from this study may help to understand the role of RORs in the inter-individual variation of SULT2A1 gene expression and the propensity to cholestasis in patients.

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