Center Publications

Center Publications Since 2008


2014

Zhang X, Liu K, Huang Y, Xu J, Li J, Ma X, Li S. Reduction-Sensitive Dual Functional Nanomicelles for Improved Delivery of Paclitaxel. Bioconjug Chem. 2014 Aug 14. [Epub ahead of print]

Liu K, Li F, Lu J, Liu S, Dorko K, Xie W, Ma X. Bedaquiline metabolism: enzymes and novel metabolites. Drug Metab Dispos. 2014; 42(5):863-6.

Wu Z, Zhang X, Xu X, Chen Y, Hu T, Kang Z, Li S, Wang H, Liu W, Ma X,Guan M. The mutation profile of JAK2 and CALR in Chinese Han patients with Philadelphia chromosome-negative myeloproliferative neoplasms. J Hematol Oncol. 2014; 7(1):48

Liu K, Li F, Lu J, Gao Z, Klaassen CD, Ma X. Role of CYP3A in isoniazid metabolism in vivo. Drug Metab Pharmacokinet.2014; 29(2):219-22.

McGill MR, Li F, Sharpe MR, Williams CD, Curry SC, Ma X, Jaeschke H. Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. Arch Toxicol. 2014; 88(2):391-401.

Li F, Lu J, Ma X. CPY3A4-mediated-hydroxyaldehyde formation in saquinavir metabolism. Drug Metab Dispos. 2014; 42(2):213-20

Bhushan B, Borude P, Edwards G, Walesky C, Cleveland J, Li F, Ma X, Apte U. Role of bile acids in liver injury and regeneration following acetaminophen overdose. Am J Pathol. 2013; 183(5):1518-26.

Zhang, P., Huang, Y., Liu, H., Marquez, R., Lu, J., Zhao, W., Zhang, X., Gao, X., Li, J., Venkataramanan, R., Xu, L., Li, S. A PEG-Fmoc conjugate as a nanocarrier for paclitaxel. Biomaterials (in press).

Zhang, X., Liu, K., Huang, Y., Xu, J., Li, J., Ma, X., and Li, S. Reduction-sensitive dual functional nanomicelles for improved delivery of paclitaxel. Molecular Pharmaceutics (in press).

Zhang, X., Liu, K., Huang, Y., Xu, J., Li, J., Ma, X., and Li, S. Reduction-sensitive dual functional nanomicelles for improved delivery of paclitaxel. Bioconjugate Chemistry (in press).

Zhou, P., Huang, G., Zhao, Y., Zhong, D., Xu, Z., Zeng, Y., Zhang, Y., Li, S., He, F. MicroRNA- 363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells. Cellular Signalling. 2014 26: 1347-54, 2014. (PMID: 24631531).

Chen, Y., Zhang, X., Lu, J., Huang, Y., Li, J., and Li, S. Targeted delivery of curcumin to tumors via PEG-derivatized FTS-based micellar system. AAPS Journal 16: 600-608, 2014. (PMID: 24706375).

Zhang, Y., Ghazwani, M., Li, J., Sun, M., Stolz, D.B., He, F., Fan, J., Xie, W., and Li, S. MiR- 29b inhibits collagen maturation in hepatic stellate cells through down-regulating the expression of HSP47 and lysyl oxidase. Biochemical and Biophysical Research Communications 446: 940- 946, 2014 (PMID: 24650661).

Zhang, P., Lu, J., Huang, Y., Zhao, W., Zhang, Y., Zhang, X., Li, J., Venkataramanan, R., Gao, X., and Li, S. Design and evaluation of a PEGylated lipopeptide equipped with drug-interactive motifs as an improved drug carrier. AAPS Journal 16: 114-124, 2014 (PMID: 24281690).

Lu, J., Huang, Y., Zhao, W., Li, J., Gao, X., Venkataramanan, R., and Li, S. Design and characterization of PEG-derivatized vitamin E as a nanomicellar formulation for delivery of paclitaxel. Molecular Pharmaceutics 10: 2880-2890, 2013 (PMID: 23768151)

Ghazwani, M., Zhang, Y., Gao, X., Fan, J., Li, J., and Li, S. Anti-fibrotic effect of thymoquinone on hepatic stellate cells.Phytomedicine 21: 254-260, 2014 (PMID: 24182989).

Liu, Z., Jiang, Y., Li, Y., Wang, J., Fan, L., Scott, M.J., Xiao, G., Li, S., Billiar, T.R., Wilson, M.A., Fan, J. TLR4 signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 (GRK2) translocation. Journal of Immunology 191: 857-864, 2013 (PMID: 23772028)

Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Crit Rev Toxicol. 44: 64-82 (2014) (Peer-reviewed review article) PMID: 24180433

Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Crit Rev Toxicol. 44: 64-82 (2014) (Peer-reviewed review article) PMID: 24180433

Liu K, Li F, Lu J, Liu S, Dorko K, Xie W, Ma X. Bedaquiline metabolism: enzymes and novel metabolites. Drug Metab Dispos. 42: 863-866 (2014) PMID: 24513655

Jiang M, He J, Kucera H, Gaikwad N, Zhang B, Xu M, O’Doherty RM, Selcer KW, Xie W. Hepatic over-expression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms. J Biol Chem. 289: 8086-8097 (2014) PMID: 24497646

Zhang Y, Ghazwani M, Li J, Sun M, Stolz DB, He F, Fan J, Xie W, Li S. MiR-29b inhibits collagen maturation in hepatic stellate cells through down-regulating the expression of HSP47 and lysyl oxidase. Biochem Biophys Res Commun. 446: 940-944 (2014) PMID: 24650661

Ihunnah CA, Wada T, Philips BJ, Ravuri SK, Gibbs RB, Kirisci L, Rubin JP, Marra KG, Xie W. Estrogen sulfotransferase (EST/SULT1E1) promotes human adipogenesis. Mol Cell Biol. 34: 1682-1694 (2014) PMID: 24567372

Zhong L, Yang Q, Xie W, Zhou J. Liver X receptor regulates mouse GM-CSF-derived dendritic cell differentiation in vitro. MolImmunol. 60: 32-43 (2014). PMID: 24747959

Wang J, Dai S, Guo Y, Xie W, Zhai Y. Biology of PXR: role in drug-hormone interactions. EXCLI Journal 13: 728-739 (2014) (Peer-reviewed review article)

Ou Z, Jiang M, Hu B*, Huang Y, Xu M, Ren S, Li S, Liu S, Xie W, Huang M. Transcriptional regulation of human hydroxysteroid sulfotransferase SULT2A1 by LXRα. Drug Metab Dispos. 2014 Jul 15. [Epub ahead of print] PMID: 25028566

Yan J, Xie W. Decipher the role of constitutive androstane receptor in energy metabolism. Acta Pharmacologica Sinica (Accepted) (Peer-reviewed review article)


2013

Tasaki T, Kim ST, Zakrzewska A, Lee BE, Kang M, Yoo YD, Hwang J, Sung NK, Sung KS, Kim S, Nguyen MD, Sun M, Yi EC, Kim BY, and Kwon YT. UBR4, an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proc. Natl. Acad. Sci. USA 110:3800-3805 (2013).

Kim ST, Tasaki T, Zakrzewska A, Yoo YD, Sung KS, Kim S, Cha-Molstad H, Hwang J, Kim KA, Kim BY, and Kwon YT. The N-end rule proteolytic system in autophagy. Autophagy. In Press. (2013).

Boso G, Tasaki T, Kwon YT, and Somia NV. The N-end rule and retroviral infection: no effect on integrase. Virology J. In Press. (2013).

Zhang G, Lin R, Kwon YT, and Li Y. Signaling mechanism of tumor cell-induced upregulation of E3 ubiquitin ligase UBR2/E3-II. FASEB J. 27:2893-2901. (2013).

Kang M, Kim HP, Lee KS, Yoo YD, Kwon YT, Kim TY, and Yi EC. Proteomic analysis reveals that CD147/EMMPRIN confers chemoresistance in cancer stem cell-like cells. Proteomics 13:1714-1725. (2013).

Yoo YD, Han DH, Jang JM, Zakrzewska A, Kim SY, Lee YJ, and Kwon YT. Molecular characteristics of cancer stem-like cells derived from human breast cancer cells. Anticancer Res. 33:763-777. (2013).

Song X, Kim S, Zhou Z, Lagasse E, Kwon YT, and Lee YJ. Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells. Cell Death Diseases. In Press. (2013).

Kim SO, Sakchaisri K, Soung NK, Jang JH, Kim YS, Lee KS, Kwon YT, Asami Y, Ahn JS, Erikson RL, and Kim BY. STK295900, a Dual Inhibitor of Topoisomerase 1 and 2, Induces G(2) Arrest in the Absence of DNA Damage. PLoS One8:e53908. (2013).

Kim SY, Kang JW, Song X, Kim BK,Yoo YD, Kwon YT, and Lee YJ. Role of the IL-6-JAK1- STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. Cell Signalling. In Press. (2013).

Kim SY, Kang JW, Song X, Kim BK,Yoo YD, Kwon YT, and Lee YJ. Role of the IL-6-JAK1- STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells. Cell Signalling. In Press. (2013).

He L, Lee J, Jang JH, Sakchaisri K, Hwang J, Cha-Molstad HJ, Kim KA, Ryoo IJ, Lee HG, Kim SO, Soung NK, Lee KS, Kwon YT, Erikson RL, Ahn JS, Kim BY. Osteoporosis regulation by salubrinal through eIF2a mediated differentiation of osteoclast and osteoblast. Cell Signalling 25:552-560. (2013).

Huong PT, Soung NK, Jang JH, Cha-Molstad HJ, Sakchaisri K, Kim SO, Jang JM, Kim KE, Lee KS, Kwon YT, Erikson RL, Ahn JS, and Kim BY. Regulation of CEP131 gene expression by SP1. Gene 513:75-81. (2013).

Lee MK, Kim DE, Zakrzewska A, Kim S, Kim ST, Seo JW, Lee YS, Dorn II GW, Kim BY, and Kwon YT.Characterization of the arginylation branch of the N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes. J. Biol. Chem. 287:24043-24052. (2013).

Tasaki T, Sriram SM, Park KS, and Kwon YT. The N-end rule pathway. Ann. Rev. Biochem. 81:261-289. (2012).

An JY, Kim E, Zakrzewska A,Yoo YD, Jang JM, Han DH, Lee MJ, Lee YJ, Kim TY, de Rooij DJ, Kim BY, and Kwon YT. UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells.PLOS One 7:e37414. (2012).

Kwon O, Soung NK, Thimmegowda NR, Jeong SJ, Jang JH, Moon DO, Chung JK, Lee KS, Kwon YT, Erikson RL, Ahn JS, and Kim BY. Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation. Cell Signaling24:943-950. (2012).

Meisenberg C, Tait PS, Dianova II, Wright K, Edelmann MJ, Ternette N, Tasaki T, Kessler BM, Parsons JL, Kwon YT and Dianov GL. Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability. Nuc. Acids Res. 40:701- 711. (2012).

Zhang X, Lu J, Huang Y, Zhao W, Chen Y, Li J, Gao X, Venkataramanan R, Sun M, Stolz D, Zhang L, and Li S. PEG-farnesylthiosalicylate conjugate as a nanomicellar carrier for delivery of paclitaxel. Bioconjugate Chemistry 24: 464-472, 2013. PMID: 23425093

Gao X, Huang Y, Makhov AM, Epperly M, Lu J, Grab S, Zhang P, Rohan LC, Xie XQ, Wipf P, Greenberger J, and Li S. Nano-assembly of surfactants with interfacial drug-interactive motifs as tailor-designed drug carriers. Molecular Pharmaceutics10: 187-198, 2013. PMID: 23244299

Li J, Ghazwani M, Zhang Y, Lu J, Li J, Fan J, Gandhi CR, and Li S. miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression. Journal of Hepatology 58: 522-528, 2013 PMID: 23178710

Li J, Ghazwani M, Zhang Y, Lu J, Li J, Fan J, Gandhi CR, and Li S. miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression. Journal of Hepatology 58: 522-528, 2013 PMID: 23178710

Huang Y, Lu J, Gao X, Li J, Zhao W, Sun M, Stolz BD, Venkataramanan V, Rohan LC, and Li S. PEG-derivatized embelin as a dual functional carrier for the delivery of paclitaxel. Bioconjugate Chemistry 23: 1443-1451, 2012. PMID: 22681537

Gao J, Xie W. Targeting xenobiotic receptors PXR and CAR for metabolic diseases. Trends Pharmacol Sci. 33: 552-558 (2012).

Williams JA, Thomas AM, Li G, Kong B, Zhan L, Inaba Y, Xie W, Ding WX, Guo GL. Tissue specific induction of p62/Sqstm1 by farnesoid X receptor. PLoS ONE 7: e43961 (2012).

He J, Gao J, Xu M, Ren S, Stefanovic-Racic M, O’Doherty RM, Xie W. PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice. Diabetes 62: 1876-1887 (2013).

Jiang M, Xie W. Role of the constitutive androstane receptor in obesity and type 2 diabetes, a case study of the endobiotic function of a xenobiotic receptor. Drug Metab Rev. 45: 156-163 (2013).

Chai X, Zeng S, Xie W. Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond. Expert Opin Drug Metab Toxicol. 9: 253-66 (2013).

Swanson HI, Wada T, Xie W, Renga B, Zampella A, Distrutti E, Fiorucci S, Kong B, Thomas AM, Guo GL, Narayanan R, Yepuru M, Dalton J, Chiang JY. Role of nuclear receptors in lipid dysfunction and obesity-related diseases. Drug Metab Dispos. 41: 1-11 (2013).

Ou Z, Shi X, Gilroy RK, Kirisci L, Romkes M, Lynch C, Wang H, Xu M, Jiang M*, Ren S, Gramignoli R, Strom SC, Huang M,Xie W. Regulation of the human hydroxysteroid sulfotransferase SULT2A1 by ROR alpha and ROR gamma and its potential relevance to human liver diseases. Mol Endocrinol 27: 106-115 (2013).

Xiao L, Wang J, Jiang M, Xie W, Zhai Y. The emerging role of constitutive androstane receptor and its cross talk with liver X receptors and peroxisome proliferator-activated receptor alpha in lipid metabolism. Vitam Horm 91: 243-258 (2013).

He J, Hu B, Shi X, Weidert ER, Lu P, Xu M, Huang M, Kelley EE, Xie W. Activation of the aryl hydrocarbon receptor sensitizes mice to non-alcoholic steatohepatitis by deactivating the mitochondrial sirtuin deacetylase Sirt3. Mol Cell Biol33: 2047-2055 (2013).

Zhang Y, Li JL, Fu Q, Wang XD, Liu LS, Wang CX, Xie W, Chen ZJ, Shu WY, Huang M. Associations of ABCB1, NFKB1, CYP3A, and NR1I2 polymorphisms with cyclosporine trough concentrations in Chinese renal transplant recipients. Acta Pharmacol Sin. 34: 555-560 (2013).

Jin L, Feng X, Rong H, Pan Z, Inaba Y, Qiu L, Zheng W, Lin S, Wang R, Wang Z, Wang S, Liu H, Li S, Xie W, Li Y. The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism. Nat Commun. 4: 1937 (2013).

Zhang J, Wei Y, Hu B, Huang M, Xie W, Zhai Y. Activation of human stearoyl-coenzyme A desaturase 1 contributes to the lipogenic effect of PXR in HepG2 cells. PLoS ONE 8: e67959 (2013).

Kittayaruksakul S, Zhao W, Xu M, Ren S, Lu J, Wang J, Downes M, Evans RM, Venkataramanan R, Chatsudthipong V, Xie W. Identification of three novel natural product compounds that activate PXR and CAR and inhibit inflammation. Pharm Res 2013 Jul 30. [Epub ahead of print]


 2012

Meisenberg, C., P.S. Tait, I.I. Dianova, K. Wright, M.J. Edelmann, N. Ternette, T. Tasaki, B.M. Kessler, J.L. Parsons, Y.T. Kwon and G.L. Dianov. (2011) Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability. Nuc. Acids Res. 40:701-711.

Tasaki, T., S.M. Sriram, and Y.T. Kwon. (2012) The N-end rule pathway. Ann. Rev. Biochem.81:261-289.

Lee, M.J., D.E. Kim, A. Zakrzewska, S. Kim, S.T. Kim, J.W. Seo, Y.S. Lee, G.W. Dorn II, B.Y. Kim, and Y.T. Kwon. (2012) Characterization of the arginylation branch of the N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes. J. Biol. Chem. 287:24043-24052.

An. J.Y., E. Kim, A. Zakrzewska, Y.D. Yoo, J.M. Jang, D.H. Han, M.J. Lee, Y.J. Lee, T.Y. Kim, D.G. de Rooij, B.Y. Kim, andY.T. Kwon. (2012) UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells. PLOS One 7:e37414.

Kwon, O., N.K. Soung, N.R. Thimmegowda, S.J. Jeong, J.H. Jang, D.O. Moon, J.K. Chung, K.S. Lee, Y.T. Kwon, R.L. Erikson, J.S. Ahn, and Kim BY. (2012) Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation.
Cell Signaling  24:943-950.

Bai Q, Zhang X, Xu L, Kakiyama G, Heuman D, Sanyal A, Pandak WM, Yin L, Xie W, Ren S. Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepatic lipids in mouse models of nonalcoholic fatty liver disease. Metabolism 61: 836-45 (2012)

Gao J, He J, Shi X, Stefanovic-Racic M, Xu M, O’Doherty RM, Garcia-Ocana A, Xie W. Sex-specific effect of estrogen sulfotransferase (EST) on mouse models of type 2 diabetes. Diabetes 61: 1543-1551 (2012)

Williams JA, Thomas AM, Li G, Kong B, Zhan L, Inaba Y, Xie W, Ding WX, Guo GL. Tissue Specific Induction of p62/Sqstm1by Farnesoid X Receptor.  PLoS ONE 7: e43961 (2012)

Li G, Thomas AM, Williams JA, Kong B, Liu J, Inaba Y, Xie W, Guo GL. Farnesoid X receptor induces murine scavenger receptor class B type I via intron binding. PLoS ONE 7: e35895 (2012)

Gao J, Xie W. Targeting xenobiotic receptors PXR and CAR for metabolic diseases. Trends Pharmacol Sci. 33: 552-558 (2012)

Lo WS, Lim YP, Chen CC, Hsu CC, Souček P, Yun CH, Xie W, Ueng YF. A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation. Arch Toxicol.2012 Jul 12. [Epub ahead of print]

Huang, Y., Lu, J., Gao, X., Li, J., Zhao, W., Sun, M., Stolz, B.D., Venkataramanan, V., Rohan, L.C., and Li, S. PEG-derivatized embelin as a dual functional carrier for the delivery of paclitaxel. Bioconjugate Chemistry 23: 1443-1451, 2012.

Zhang, Y., Huang, Y., Zhang, P., Gao, X., Gibbs, R.B., and Li, S. Incorporation of a selective sigma-2 receptor ligand enhances uptake of liposomes by multiple cancer cells. International Journal of Nanomedicine 7: 4473-85, 2012.


2011

Goff, J., Epperly, M., Dixon, T., Wang, H., Franicola, D., Shields, D., Wipf, P., Li, S., Gao, X., and Greenberger J.S. Radiobiologic effects of GS-nitroxide (JP4-039) on the hematopoietic syndrome. In Vivo 25: 315-323, 2011

Greenberger, J.S., Clump, D., Kagan, V., Bayir, H., Lazo, J.S., Wipf, P., Li, S., Gao, X., and Epperly, M.W. Strategies for discovery of small molecule radiation protectors and radiation mitigators. Frontiers in Radiation Oncology (in press).

Ihunnah CA, Jiang M, Xie W. Nuclear Receptor PXR, transcriptional circuits and metabolic relevance. Biochim Biophys Acta 1812: 956-963 (2011)

He J, Nishida S, Xu M, Makishima M, Xie W. PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts. Gastroenterology 140: 2095-2106 (2011)

He J, Lee JH, Febbraio M, Xie W. The emerging roles of fatty acid translocase (FAT)/CD36 and the aryl hydrocarbon receptor (AhR) in fatty liver disease. Exp Biol Med (Maywood). 236: 1116–1121 (2011)

He, L., J.H. Jang, H.G. Choi, S.M. Lee, M.H. Nan, S.J. Jeong, Z.D., Y.T. Kwon, K.S. Lee, K.W. Lee, J.K. Chung, J.S. Ahn and B.Y. Kim. (2011) Oligomycin A Enhances Apoptotic Effect of TRAIL through CHOP-mediated Death Receptor 5 Expression.Mol. Carcinogenesis (in press).

Kang HS, Okamoto K, Takeda Y, Beak JY, Gerrish KE, Bortner CD, Degraff LM, Wada T, Xie W, Jetten AM. Transcriptional profiling reveals a role for RORα in regulating gene expression in obesity-associated inflammation and hepatic steatosis.Physiol Genomics 43: 818-828 (2011)

Kim, H., Bernard, M.E., Epperly, M.W., Shen, H., Amoscato, A., Dixon, T.M., Doemling, A.S., Li, S., Gao, X., Wipf, P., Wang, H., Zhang, X., Kagan, V.E., and Greenberger, J.S. Amelioration of Radiation Esophagitis by Orally Administered p53/Mdm2/Mdm4 Inhibitor (BEB55) or GS-Nitroxide. In Vivo 25: 841-848, 2011

Li, J., Zhang, Y., Kuruba, R., Gao, X., Gandhi, C.R., Xie, W., and Li, S. Roles of miR-29a in the antifibrotic effect of FXR in hepatic stellate cells. Molecular Pharmacology 80: 191-200, 2011.

Meisenberg, C., P.S. Tait, I.I. Dianova, K. Wright, M.J. Edelmann, N. Ternette, T. Tasaki, B.M. Kessler, J.L. Parsons, Y.T. Kwon and G.L. Dianov. (2011) Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability. Nuc. Acids Res. (in press)

Ou Z, Wada T, Gramignoli R, Li S, Strom SC, Huang M, Xie W. MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feed-back loop of LXRα autoregulation. Mol Endocrinol 25: 584-96 (2011)

Saini SP, Zhang, Niu Y, Jiang M, Gao J, Zhai Y, Lee JH, Uppal H, Tian H, Tortorici MA, Poloyac SM, Qin W, Venkataramanan R, Xie W. Activation of LXR increases acetaminophen clearance and prevents its toxicity in mice. Hepatology (In press)

Sriram, S.M., B.Y. Kim, and Y.T. Kwon. (2011) The N-end rule pathway: emerging functions and molecular principles of substrate recognition. Nat. Rev. Mol. Cell. Biol. 12:735-747.

Sriram, S.M., D.H. Han, and S.T. Kim. (2011) Partners in crime: ubiquitin-mediated degradation and autophagy. Science Signal. 4:jc4, 2011.

Tasaki, T., S.M. Sriram, and Y.T. Kwon. (2012) The N-end rule pathway. Ann. Rev. Biochem. (In press).

Wada T, Ihunnah CA, Gao J, Chai X, Zeng S, Philips BJ, Rubin JP, Marra KG, Xie W. Estrogen sulfotransferase inhibits adipocyte differentiation. Mol Endocrinol 25: 1612-1623 (2011)


2010

An, J.Y., E. Kim, Y. Jiang, A. Zakrzewska, D.E. Kim, M.J. Lee, I. Mook-Jung, Y. Zhang, and Y.T. Kwon. (2010) UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. Proc. Natl. Acd. Sci. USA. 107:1912-1917.

Epperly, M.W., Goff, J.P., Li, S., Gao, X., Wipf, P., Dixon, T., Wang, H., Franicola, D., Shen, H., Rwigema, J-C.M., Kagan, V., Bernard, M., and Greenberger, J.S. Intraesophageal administration of GS-Nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis. In Vivo 24: 811-819, 2010

Chao, F, Gong, W., Zheng, Y., Li, Y., Huang, G., Gao, M., Li, J., Kuruba, R., Gao, X., Li, S., and He, F. Upregulation of scavenger receptor class B type I expression by activation of FXR in hepatocyte. Atherosclerosis 213: 443-448, 2010

Gao J, Xie W. PXR and CAR at the crossroad of drug metabolism and energy metabolism. Drug Metab Dispos 38: 2091-2095 (2010)

Gong, W., Zheng, Y., Chao, F., Li, Y., Xu, Z., Huang, G., Gao, X., Li, S., and He, F. The anti-inflammatory activity of HMGB1 A box is enhanced when fused with C-terminal acidic tail. Journal of Biomedicine and Biotechnology 2010: 915234, 2010

He J, Cheng Q, Xie W. Nuclear receptor-controlled steroid hormone synthesis and metabolism. Mol Endocrinol. 24: 11-21 (2010)

Jin L, Martynowski D, Zheng S, Wada T, Xie W, Li Y. Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORγ. Mol Endocrinol. 24: 923-929 (2010)

Kang HS, Okamoto K, Kim YS, Takeda Y, Bortner CD, Dang H, Wada T, Xie W, Yang XP, Liao G, Jetten AM. Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance. Diabetes 60: 177-188 (2010)

Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, Gonzalez FJ, Xie W. A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology 139: 653-63 (2010)

Li, J., Kuruba, R., Wilson, A., Gao, X., Zhang, Y., and Li, S. Inhibition of endothelin-1-mediated contraction of hepatic stellate cells by FXR ligand. Plos One 5: e13955, 2010.

Ou Z, Huang M, Zhao L, Xie W. Use of transgenic mice in UDP-glucuronosyltransferase (UGT) studies. Drug Metab Rev. 42: 119-127 (2010)

Song, J.J., M. Szczepanski, D. Bartlett, Y.T. Kwon, M.A. Alcala, and Y.J. Lee. (2010) c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance. Cell. Signaling. 22:553-563.

Sriram, S.M. and Y.T. Kwon. (2010) The molecular principles of N-end rule recognition. Nat. Struct. Mol. Biol. 17:1164-1165.

Yang, F. Y. Cheng, Y.T. Kwon, S. Eckardt, N.A. Leu, K.J. McLaughlin, and P.J. Wang. (2010) UBR2, the ubiquitin E3 ligase of the N-end rule pathway, interacts with and stabilizes TEX19 in spermatogenesis. PLOS One 5:e14017.

Zhai Y, Wada T, Zhang B, Khadem S, Ren S, Kuruba R, Li S, Xie W. A functional crosstalk between LXRa and CAR links lipogenesis and xenobiotic responses. Mol Pharmacol 78: 666-674 (2010)

Zhang B, Cheng Q, Ou Z, Lee JH, Xu M, Kochhar U, Ren S, Huang M, Pflug BR, Xie W. Pregnane X receptor as a therapeutic target to inhibit androgen activity. Endocrinology 151: 5721-5729 (2010)


2009

Gao J, He J, Zhai Y, Wada T, Xie W. The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity. J Biol Chem. 284: 25984-25992 (2009)

Gao, X., Kuruba, R., Achary, D.K., Day, B.W., Liu, D., and Li, S. Polyhydroxylalkyleneamines: a class of hydrophilic polymer-based gene transfer agents. Journal of Controlled Release 137: 38-45, 2009.

Gong H, He J, Lee JH, Mallick E, Gao X, Li S, Homanics GE, Xie W. Activation of the liver X receptor prevents lipopolysaccharide-induced lung injury. J Biol Chem. 284: 30113-30121 (2009)

Gong H, Zhang B, Schutz-Geschwender A, Kovar JL, Little G, Chen H, Xie W, Olive DM. b-galactosidase activity assay using far red-shifted fluorescent substrate DDAOG. Analytical Biochemistry 386: 59-64 (2009)

Jeong, J.H., J.Y. An, Y.T. Kwon, J.G. Rhee, and Y.J. Lee. (2009) Effects of low dose quercetin: Cancer cell-specific inhibition of cell cycle progression. J. Cell Biochem. 106:73-82.

Kuruba, R., Wilson, A., Gao, X., and Li, S. Targeted delivery of nucleic acids-based therapeutics to pulmonary circulation.The AAPS Journal 11: 23-30, 2009.

Li, J., Wilson, A., Gao, X., Kuruba, R., Liu, Y.H., Poloyac, S., Pitt, B., Xie, W., and Li, S. Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginine. Journal of Pharmacology and experimental Therapeutics 331: 234-243, 2009.

Liu MJ, Takahashi Y, Wada T, He J, Gao J, Tian Y, Li S, Xie W. The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors PXR and CAR. Molecular Pharmacology 76: 604-611 (2009)

Lu Y, Chen Q, Corey E, Xie W, Fan J, Mizokami A, Zhang J. Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone. Clin Exp Metastasis 26: 161-169 (2009)

Sriram, S.M., R.S. Kane, and Y.T. Kwon. (2009) Multivalency-assisted control of intracellular signaling pathways: application for ubiquitin-dependent N-end rule pathway. Chem. Biol. 16:121-131.

Tasaki, T., A. Zakrzewska, D.D. Dudgeon, Y. Jiang, J.S. Lazo, and Y.T. Kwon. (2009) The substrate recognition domains of the N-end rule pathway. J. Biol. Chem. 284:1884-1895.

Tortorici MA, Mu Y, Kochanek PM, Xie W, Poloyac SM. Moderate hypothermia prevents cardiac arrest-mediated suppression of drug metabolism and induction of interleukin-6 in rats. Crit Care Med. 37: 263-269 (2009)

Wada T, Gao J, Xie W. PXR and CAR in energy metabolism. Trends Endocrinol Metab 20: 273-279 (2009)

Xie Y, Ke S, Ouyang N, He J, Xie W, Bedford MT, Tian Y. Epigenetic regulation of the transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. J Biol Chem. 284: 9199-9205 (2009)


2008

Gong H, Jarzynka MJ, Cole TJ, Lee JH, Wada T, Zhang B, Gao J, Song WC, DeFranco DB, Cheng SY, Xie W.  Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase. Cancer Research 68: 7386-7393 (2008)

He, F., Zhang, Q., Kuruba, R., Gao, X., Li, J., Li, Y., Gong, W., Jiang, Y., Xie, W., and Li, S. Upregulation of decorin by FXR in vascular smooth muscle cells. Biochemical and Biophysical Research Communications 372: 746-751, 2008.

Jeong, J.H., J.Y. An, Y.T. Kwon, L. Li, and Y.J. Lee. Quercetin-induced ubiquitination and down-regulation of Her-2/neu. (2008) J. Cell. Biochem. 105:585-595.

Lee JH, Zhou J, and Xie W. PXR And LXR in hepatic steatosis, a new dog and an old dog with new tricks. Molecular Pharmaceutics 5: 60-66 (2008)

Lee JH, Gong H, Khadem S, Lu Y, Gao X, Li S, Zhang J, Xie W. Androgen deprivation by activating the liver X receptor.Endocrinology 149: 3778-3788 (2008)

Lee, M. J.K. Pal, T. Tasaki, S. Roy, Y. Jiang, J.Y. An, R. Banerjee, and Y.T. Kwon. (2008) Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway. Proc. Natl. Acad. Sci. USA 105:100-105.

Li, J., Wilson, A., Kuruba, R., Zhang, Q., Gao, X., He, F., Zhang, L.M., Pitt, B.R., Xie, W., and Li, S. FXR-mediated regulation of eNOS expression in vascular endothelial cells. Cardiovascular Research 77: 169-177, 2008.

Straub, A.C., Clark, K.A., Ross, M.A., Chandra, A.G., Li, S., Gao, X., Pagano, P.J., Stolz, D.B., and Barchowsky, A. Arsenic-stimulated sinusoidal capillarization in mice requires NADPH oxidase generated superoxide. Journal of Clinical Investigation 118: 3980-3989, 2008

Uppal H, Zhai Y, Gangopadhyay A, Khadem S, Ren S, Moser JA, and Xie W. Activation of LXR sensitizes mice to gallbladder cholesterol crystallization. Hepatology 47: 1331-1342 (2008)

Wada T, Kang HS, Jetten AM, and Xie W. The emerging role of nuclear receptor RORa and its crosstalk with LXR in xeno- and endobiotic gene regulation. experimental Biology and Medicine 233: 1191-1201 (2008)

Wada T, Kang SH, Angers M, Gong H, Bhatia S, Khadem S, Ren S, Ellis E, Strom SC, Jetten AM, and Xie W. Identification of oxysterol 7a-hydroxylase (Cyp7b1) as a novel RORa target gene and a functional crosstalk between RORa and LXR.Molecular Pharmacology 73: 891-899 (2008)

Wang H, Li H, Moore LB, Johnson MDL, Maglich JM, Goodwin B, Ittoop ORR, Wisely B, Creech K, Parks DJ, Collins JL, Wilson TM, Kalpana GV, Venkatesh M, Xie W, Cho SY, Roboz J, Redinbo M, Moore JT, and Mani S. The phytoestrogen coumestrol is a naturally-occurring antagonist of the human pregnane X receptor (PXR). Molecular Endocrinology 22: 838-857 (2008)

Wang K, Chen S, Xie W, and Wan YJ. Retinoids induce cytochrome P450 3A4 through RXR/VDR-mediated pathway.Biochem Pharmacol. 75: 2204-2213 (2008)

Zhang B, Xie W, and Krasowski MD. PXR, a xenobiotic receptor of diverse function and implicated in pharmacogenetics.Pharmacogenomics 9: 1695-1709 (2008)

Zhang, Q., He, F., Kuruba, R., Gao, X., Wilson, A., Li, J., Billiar, T.R., Pitt, B.R., Xie, W., and Li, S. FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells. Cardiovascular Research 77: 560-569, 2008.

Zhou J, Liu MJ, Zhai Y, and Xie W. The anti-apoptotic role of pregnane X receptor in human colon cancer cells. Molecular Endocrinology 22: 868-880 (2008)

Zhou J, Febbraio M, Wada T, Zhai Y, Kuruba R, Khadem S, He J, Lee JH, Ren S, Li S, Silverstein RL, and Xie W. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR and PPARg in promoting lipogenesis. Gastroenterology 134: 556-567 (2008)